Prolactin response to low dose sulpiride.

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Prolactin response to low dose sulpiride.

1 Prolactin levels in response to sulpiride were studied in healthy volunteers. 2 Oral doses of 1 mg-50 mg sulpiride or placebo were given. 3 A 3 mg sulpiride dose produced similar levels to those achieved with both 10 mg and 50 mg. 4 Circadian effects were studied showing no significant differences in the prolactin response to sulpiride. 5 Acute or chronic responses showed an attenuation with ...

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RAPID COMMUNICATION Stimulation of Human Prolactin Secretion by Sulpiride

Recent studies have demonstrated that psychotropic drugs such as reserpine and chlorpromazine cause a significant increase in plasma human prolactin (hPRL) levels, frequently inducing galactorrhea (Frantz et al., 1972). Chlorpromazine is now commonly used as a means of stimulating hPRL secretion in man (Friesen et al., 1972; Turkington, 1972). Borenstein et al. (1968) first reported that galact...

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Low prolactin response to fenfluramine in impulsive aggression.

To examine the prolactin (prl) response to d,l-fenfluramine in a large sample of personality disorder patients with impulsive aggression. Patients were screened from clinics at the Bronx VAMC and the Mount Sinai Medical Center and from press releases. One hundred and forty-six personality disorder patients (90M;56F) and 23 normal controls (15M;8F) underwent oral d,l-fenfluramine challenge. The ...

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Sulpiride stimulation of prolactin secretion in adolescents with gynecomastia: relation to the circulating levels of estradiol.

Basal leveis of prolactin (PRL) and estradiol (E,) were studied in 10 adolescents with gynecomastia who were ar stages 11 ro IV of rheir sexual developmenr. In 7 of the 10 patients, the hypophyseal response of PRL ro the administracion of sulpiride was assessed: 5 of rhe 7 received 25 mg i.m., and the remaining 50 rng. i.m. The 10 cases were compared wirh 12 control boys wirhour gynecomastia rn...

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Human in vivo dose-response to controlled, low-dose low linear energy transfer ionizing radiation exposure.

PURPOSE The effect of low doses of low-linear energy transfer (photon) ionizing radiation (LDIR, <10 cGy) on human tissue when exposure is under normal physiologic conditions is of significant interest to the medical and scientific community in therapeutic and other contexts. Although, to date, there has been no direct assessment of the response of human tissue to LDIR when exposure is under no...

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 1987

ISSN: 0306-5251

DOI: 10.1111/j.1365-2125.1987.tb03153.x